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エストロゲン受容体α

出典: フリー百科事典『ウィキペディア（Wikipedia）』
（ESR1から転送）
ESR1
PDBに登録されている構造
PDBオルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧

1A52, 1ERE, 1ERR, 1G50, 1GWQ, 1GWR, 1HCP, 1HCQ, 1L2I, 1PCG, 1QKT, 1QKU, 1R5K, 1SJ0, 1UOM, 1X7E, 1X7R, 1XP1, 1XP6, 1XP9, 1XPC, 1XQC, 1YIM, 1YIN, 1ZKY, 2AYR, 2B1V, 2B1Z, 2B23, 2BJ4, 2FAI, 2G44, 2G5O, 2I0J, 2IOG, 2IOK, 2JF9, 2JFA, 2LLO, 2LLQ, 2OCF, 2OUZ, 2P15, 2POG, 2Q6J, 2Q70, 2QA6, 2QA8, 2QAB, 2QE4, 2QGT, 2QGW, 2QH6, 2QR9, 2QSE, 2QXM, 2QXS, 2QZO, 2R6W, 2R6Y, 2YAT, 2YJA, 3CBM, 3CBO, 3CBP, 3DT3, 3ERD, 3ERT, 3HLV, 3HM1, 3L03, 3OS8, 3OS9, 3OSA, 3Q95, 3Q97, 3UU7, 3UUA, 3UUC, 3UUD, 4AA6, 4DMA, 4IU7, 4IUI, 4IV2, 4IV4, 4IVW, 4IVY, 4IW6, 4IW8, 4IWC, 4IWF, 4JC3, 4JDD, 4MG5, 4MG6, 4MG7, 4MG8, 4MG9, 4MGA, 4MGB, 4MGC, 4MGD, 4O6F, 4PP6, 4PPP, 4PPS, 4PXM, 4Q13, 4Q50, 4TUZ, 4TV1, 5AK2, 5AAV, 5ACC, 5AAU, 4XI3, 4ZN9, 5FQS, 5FQR, 5FQP, 5FQT, 5FQV, 4ZN7, 5E0W, 5DUG, 4ZUC, 5DXK, 5E19, 5DXQ, 5EI1, 5DXR, 5DVS, 5DZ1, 5E0X, 5DKB, 5DWI, 5E14, 5DXB, 5BPR, 5EIT, 5E15, 4ZNS, 5EGV, 5DL4, 5DWE, 4ZNT, 5EHJ, 5DYD, 5DWG, 4ZNV, 5DWJ, 5DID, 4ZUB, 5BNU, 5DMC, 5DK9, 5DIG, 5DUH, 5DKS, 5DMF, 5DU5, 5DY8, 4ZWH, 5DVV, 5DLR, 4ZWK, 5DRM, 5DP0, 5DKE, 5DZI, 5DZ3, 4ZNU, 5DIE, 5DZ0, 5E1C, 5HYR, 5BQ4, 4ZNW, 5DUE, 5DTV, 5DRJ, 5DKG, 4ZNH, 5BP6, 5DXG, 5DI7, 5DX3, 5DYB, 5DXP, 5DZH, 5DXM

識別子
記号ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1, estrogen receptor 1
外部IDOMIM: 133430 MGI: 1352467 HomoloGene: 47906 GeneCards: ESR1
遺伝子の位置 (ヒト)
6番染色体 (ヒト)
染色体6番染色体 (ヒト)[1]
6番染色体 (ヒト)
ESR1遺伝子の位置
ESR1遺伝子の位置
バンドデータ無し開始点151,656,691 bp[1]
終点152,129,619 bp[1]
遺伝子の位置 (マウス)
10番染色体 (マウス)
染色体10番染色体 (マウス)[2]
10番染色体 (マウス)
ESR1遺伝子の位置
ESR1遺伝子の位置
バンドデータ無し開始点4,561,593 bp[2]
終点4,955,614 bp[2]
遺伝子オントロジー
分子機能• DNA-binding transcription factor activity
• DNA-binding transcription activator activity, RNA polymerase II-specific
• nitric-oxide synthase regulator activity
• nuclear receptor activity
• estrogen response element binding
• 転写因子結合
• 金属イオン結合
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• steroid hormone receptor activity
• ステロイド結合
• beta-catenin binding
• zinc ion binding
• クロマチン結合
• 血漿タンパク結合
• DNA結合
• sequence-specific DNA binding
• ATPase binding
• identical protein binding
• 脂質結合
• core promoter sequence-specific DNA binding
• 酵素結合
• プロテインキナーゼ結合
• TFIIB-class transcription factor binding
• TBP-class protein binding
• estrogen receptor activity
• estrogen receptor binding
• transcription coactivator binding
• phosphatidylinositol-4,5-bisphosphate 3-kinase activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
細胞の構成要素• 細胞質
• 膜
• 細胞核
• integral component of membrane
• ゴルジ体
• 細胞膜
• 核質
• transcription preinitiation complex
• 細胞質基質
• 高分子複合体
生物学的プロセス• epithelial cell development
• positive regulation of phospholipase C activity
• mammary gland alveolus development
• transcription by RNA polymerase II
• phospholipase C-activating G protein-coupled receptor signaling pathway
• epithelial cell proliferation involved in mammary gland duct elongation
• prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
• protein localization to chromatin
• steroid hormone mediated signaling pathway
• regulation of apoptotic process
• クロマチンリモデリング
• regulation of transcription, DNA-templated
• アンドロゲン代謝プロセス
• positive regulation of fibroblast proliferation
• mammary gland branching involved in pregnancy
• 遺伝子発現の負の調節
• transcription, DNA-templated
• negative regulation of DNA-binding transcription factor activity
• cellular response to estrogen stimulus
• positive regulation of transcription, DNA-templated
• positive regulation of nitric-oxide synthase activity
• transcription initiation from RNA polymerase II promoter
• regulation of branching involved in prostate gland morphogenesis
• 男性生殖腺発生
• positive regulation of DNA-binding transcription factor activity
• negative regulation of transcription by RNA polymerase II
• negative regulation of I-kappaB kinase/NF-kappaB signaling
• negative regulation of production of miRNAs involved in gene silencing by miRNA
• response to estrogen
• 子宮発生
• prostate epithelial cord elongation
• antral ovarian follicle growth
• 膣発生
• positive regulation of cytosolic calcium ion concentration
• positive regulation of nitric oxide biosynthetic process
• シグナル伝達
• positive regulation of transcription by RNA polymerase II
• intracellular steroid hormone receptor signaling pathway
• regulation of inflammatory response
• エストラジオールへの反応
• regulation of toll-like receptor signaling pathway
• regulation of transcription by RNA polymerase II
• protein deubiquitination
• cellular response to estradiol stimulus
• intracellular estrogen receptor signaling pathway
• positive regulation of RNA polymerase II transcription preinitiation complex assembly
• stem cell differentiation
• regulation of Wnt signaling pathway
• regulation of intracellular estrogen receptor signaling pathway
• phosphatidylinositol phosphate biosynthetic process
• positive regulation of protein kinase B signaling
出典:Amigo / QuickGO
オルソログ
種ヒトマウス
Entrez

2099

13982

Ensembl

ENSG00000091831

ENSMUSG00000019768

UniProt

P03372

P19785

RefSeq
(mRNA)
NM_000125
NM_001122740
NM_001122741
NM_001122742
NM_001291230

NM_001291241
NM_001328100
NM_001385568
NM_001385569
NM_001385570
NM_001385571
NM_001385572

NM_007956
NM_001302531
NM_001302532
NM_001302533

RefSeq
(タンパク質)
NP_000116
NP_001116212
NP_001116213
NP_001116214
NP_001278159

NP_001278170
NP_001315029

NP_001289460
NP_001289461
NP_001289462
NP_031982

場所
(UCSC)		Chr 6: 151.66 – 152.13 MbChr 6: 4.56 – 4.96 Mb
PubMed検索[3][4]
ウィキデータ
閲覧/編集 ヒト閲覧/編集 マウス

エストロゲン受容体α（英: estrogen receptor alpha、略称: ERα）またはNR3A1（nuclear receptor subfamily 3, group A, member 1）は、エストロゲン受容体の主要な2つのタイプのうちの1つである。エストロゲン受容体は性ホルモンであるエストロゲンによって活性化される核内受容体である。ヒトでは、ERαはESR1遺伝子にコードされる[5][6][7]。

構造

[編集]

エストロゲン受容体（ER）はリガンド活性化型転写因子であり、ホルモンの結合、DNAへの結合、転写活性化に重要ないくつかのドメインから構成される[8]。ESR1遺伝子からは選択的スプライシングによっていくつかの種類のmRNA転写産物が生じるが、これらは主に5' UTRが異なり、翻訳される受容体タンパク質の多様性は低い[5][9]。

リガンド

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アゴニスト

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非選択的

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選択的

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ERβ（英語版）よりもERαに選択的なアゴニスト

Mixed

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アンタゴニスト

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非選択的

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選択的

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ERβよりもERαに選択的なアンタゴニスト

親和性

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→「en:Template:Affinities_of_estrogen_receptor_ligands_for_the_ERα_and_ERβ」を参照

組織分布と機能

[編集]

ERαは程度の差こそあれ、生殖器、中枢神経系、骨格筋、心血管系などさまざまな器官の生理学的な発生と機能に関与しており[10]、子宮、卵巣、男性器、乳腺、骨、心臓、視床下部、脳下垂体、肝臓、肺、腎臓、脾臓、脂肪組織など体中で広く発現している[10][11][12]。ERαノックアウト（ERKO）マウスなど、活性のあるERα遺伝子を欠く動物モデルではこれらの組織の発生と機能に異常が発生し、特定の器官におけるERαの機能に関する初歩的な理解が得られている[10][13]。

子宮と卵巣

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ERαは女性器の成熟に必要不可欠である。ERKOマウスのようにERαが存在しない場合でも子宮は発生することから、ERαは子宮の初期発生を媒介しているのではない可能性が示唆される[10][11]。一方、ERαはこの発生過程の完結と、その後の組織の機能に関与している[13]。ERαの活性化は子宮での細胞増殖の引き金となることが知られている[12]。メスのERKOマウスの子宮は発育不全であり、ERαはエストロゲン刺激に応答した子宮での有糸分裂と分化を媒介していることが示唆される[11]。

同様に、性成熟前のメスのERKOマウスの卵巣の発生は野生型とほぼ区別できない。しかしながら、成熟につれて卵巣には生理と機能の双方で異常な表現型がみられるようになる[11][13]。具体的には、メスのERKOマウスでは出血性の卵胞嚢胞（英語版）を含む肥大した卵巣が発生し、また黄体を欠き、排卵は起こってない[10][11][13]。この成体の卵巣の表現型は、ERαが存在しない場合にはエストロゲンが視床下部へのネガティブフィードバックを行うことができず、慢性的な黄体形成ホルモン値の上昇と恒常的な卵巣刺激が引き起こされることを示唆している[11]。これらの結果は、ERαが卵巣の莢膜細胞や間質細胞を介したエストロゲン駆動の成熟に加えて、視床下部においても重要な役割を果たしていることを明らかにしている[11]。

男性器

[編集]

ERαは男性器の成熟と維持にも同様に重要であり、ERKOマウスは不妊で精巣のサイズが小さい[10][13]。ERKOマウスでは、精細管や精上皮などの精巣構造の完全性が経時的にに低下する[10][11]。さらに、オスのERKOマウスの生殖能力は精子形成障害、交尾器官や射精反応の喪失といった性生理や性行動の異常によって妨げられる[10][11]。

乳腺

[編集]

エストロゲンによるERαの刺激は、乳房組織で細胞増殖を刺激することが知られている[12]。ERαはエストロゲンに対する乳腺の応答を媒介することで、思春期における成体表現型の発生を担うと考えられている[13]。この役割はメスのERKOマウスでみられる異常と一致しており、ERKOマウスでは乳管（英語版）は性成熟前の長さ以上に成長することはなく、授乳のための構造は発生しない[11]。その結果、授乳やプロラクチンの放出といった乳腺の機能が大きく損なわれる[13]。

骨

[編集]

骨におけるERαの発現は中程度であるが、骨の完全性の維持を担っていることが知られている[12][13]。エストロゲンによるERαの刺激は上皮成長因子やIGF-1などの成長因子の放出を開始し、骨の発生と維持を調節している可能性がある[11][13]。オスとメスのERKOマウスでは、骨の長さとサイズが低下する[11][13]。

脳

[編集]

ERαを介したエストロゲン刺激は、シナプス形成やシナプス可塑性（英語版）など、中枢神経発生のさまざまな側面を担っているようである[13]。脳では、ERαは視床下部、視索前野（英語版）、弓状核（英語版）に存在する。これら3つの領域は全て生殖行動と関連付けられており、マウスの脳の男性化はERαの機能を介して行われているようである[10][13]。さらに、精神病理や神経変性疾患モデルの研究からは、脳におけるエストロゲンの神経保護作用はエストロゲン受容体によって媒介されていることが示唆されている[10][12]。また、ERαは弓状核や前腹側室周囲核（英語版）の神経細胞でキスペプチン（英語版）の発現を増加させることで、脳での性腺刺激ホルモン放出ホルモン（GnRH）と黄体形成ホルモン（LH）分泌に対するエストロゲンのポジティブフィードバック効果を媒介しているようである[14][15]。古典的研究ではエストロゲンのネガティブフィードバック効果もERαを介して作動していることが示唆されているが、キスペプチン発現神経細胞でERαを欠くメスマウスもある程度のネガティブフィードバック応答を示し続ける[16]。

臨床的意義

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エストロゲン不応症（英語版）は、ERαがエストロゲン感受性を喪失する欠陥によって特徴づけられる、極めて稀な疾患である[17][18][19][20]。女性の臨床症状としては、乳房の発達やその他の思春期にみられる第二次性徴の欠如、子宮発育不全、原発性無月経、肥大した多嚢胞性卵巣やそれに関連した下腹部の痛み、軽度のアンドロゲン過剰症（ニキビとして表出する）、骨成熟の遅れや骨のターンオーバーの増加などが観察される[20]。男性の臨床症状としては、骨端軟骨閉鎖の欠如、高身長、骨粗鬆症、精子の生存率の低下などが報告されている[19]。どちらの場合も、外因性のエストロゲン補充療法に対しては高用量であっても全く感受性を示さない[19][20]。

ERαをコードする遺伝子の多型は、男性の女性化乳房[21]、女性の乳がん[22]、月経困難症[23]と関係している。

コアクチベーター

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ERαのコアクチベーターとしては次のようなものがある。

相互作用

[編集]

ERαは次に挙げる因子と相互作用することが示されている。

出典

[編集]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000091831 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019768 - Ensembl, May 2017
  3. ^ Human PubMed Reference:
  4. ^ Mouse PubMed Reference:
  5. ^ a b “Entrez Gene: ESR1 estrogen receptor 1”. 2022年7月30日閲覧。
  6. ^ “Cloning of the human estrogen receptor cDNA”. Proceedings of the National Academy of Sciences of the United States of America 82 (23): 7889–7893. (December 1985). Bibcode: 1985PNAS...82.7889W. doi:10.1073/pnas.82.23.7889. PMC 390875. PMID 3865204. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC390875/. 
  7. ^ “Sequence and expression of human estrogen receptor complementary DNA”. Science 231 (4742): 1150–1154. (March 1986). Bibcode: 1986Sci...231.1150G. doi:10.1126/science.3753802. PMID 3753802. 
  8. ^ “International Union of Pharmacology. LXIV. Estrogen receptors”. Pharmacological Reviews 58 (4): 773–781. (December 2006). doi:10.1124/pr.58.4.8. PMID 17132854. 
  9. ^ “Minireview: genomic organization of the human ERalpha gene promoter region”. Molecular Endocrinology 15 (12): 2057–2063. (December 2001). doi:10.1210/mend.15.12.0731. PMID 11731608. 
  10. ^ a b c d e f g h i j “Estrogen receptor signaling during vertebrate development”. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1849 (2): 142–151. (February 2015). doi:10.1016/j.bbagrm.2014.06.005. PMC 4269570. PMID 24954179. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269570/. 
  11. ^ a b c d e f g h i j k l “Estrogen receptor transcription and transactivation: Estrogen receptor knockout mice: what their phenotypes reveal about mechanisms of estrogen action”. Breast Cancer Research 2 (5): 345–352. (2000). doi:10.1186/bcr79. PMC 138656. PMID 11250727. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138656/. 
  12. ^ a b c d e “Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential”. Steroids 90: 13–29. (November 2014). doi:10.1016/j.steroids.2014.06.012. PMC 4192010. PMID 24971815. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192010/. 
  13. ^ a b c d e f g h i j k l “Functions and physiological roles of two types of estrogen receptors, ERα and ERβ, identified by estrogen receptor knockout mouse”. Laboratory Animal Research 28 (2): 71–76. (June 2012). doi:10.5625/lar.2012.28.2.71. PMC 3389841. PMID 22787479. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389841/. 
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  15. ^ “Neurobiological mechanisms underlying oestradiol negative and positive feedback regulation of gonadotrophin-releasing hormone neurones”. Journal of Neuroendocrinology 21 (4): 327–333. (March 2009). doi:10.1111/j.1365-2826.2009.01826.x. PMC 2738426. PMID 19207821. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738426/. 
  16. ^ “60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-pituitary-gonadal axis”. The Journal of Endocrinology 226 (2): T41–T54. (August 2015). doi:10.1530/JOE-15-0113. PMC 4498991. PMID 25901041. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498991/. 
  17. ^ Endocrinology: Adult and Pediatric. Elsevier Health Sciences. (February 2015). pp. 238–. ISBN 978-0-323-32195-2. https://books.google.com/books?id=xmLeBgAAQBAJ&pg=PT238 
  18. ^ “Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes”. Recent Progress in Hormone Research 51: 159–86; discussion 186–8. (1996). PMID 8701078. 
  19. ^ a b c “Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man”. The New England Journal of Medicine 331 (16): 1056–1061. (October 1994). doi:10.1056/NEJM199410203311604. PMID 8090165. 
  20. ^ a b c “Delayed puberty and estrogen resistance in a woman with estrogen receptor α variant”. The New England Journal of Medicine 369 (2): 164–171. (July 2013). doi:10.1056/NEJMoa1303611. PMC 3823379. PMID 23841731. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823379/. 
  21. ^ “Genetic variants of estrogen beta and leptin receptors may cause gynecomastia in adolescent”. Gene 541 (2): 101–106. (May 2014). doi:10.1016/j.gene.2014.03.013. PMID 24625355. 
  22. ^ “The Effects of Sex Protein Receptors and Sex Steroid Hormone Gene Polymorphisms on Breast Cancer Risk”. Journal of the National Medical Association 109 (2): 126–138. (2017). doi:10.1016/j.jnma.2017.02.003. PMID 28599754. 
  23. ^ “Estrogen receptor 1, glutathione S-transferase P1, glutathione S-transferase M1, and glutathione S-transferase T1 genes with dysmenorrhea in Korean female adolescents”. The Korean Journal of Laboratory Medicine 30 (1): 76–83. (February 2010). doi:10.3343/kjlm.2010.30.1.76. PMID 20197727. 
  24. ^ “Molecular determinants for the tissue specificity of SERMs”. Science 295 (5564): 2465–2468. (March 2002). Bibcode: 2002Sci...295.2465S. doi:10.1126/science.1068537. PMID 11923541. 
  25. ^ “Coregulator function: a key to understanding tissue specificity of selective receptor modulators”. Endocrine Reviews 25 (1): 45–71. (February 2004). doi:10.1210/er.2003-0023. PMID 14769827. 
  26. ^ “AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer”. Science 277 (5328): 965–968. (August 1997). doi:10.1126/science.277.5328.965. PMID 9252329. https://zenodo.org/record/1231118. 
  27. ^ “Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)”. Molecular Endocrinology 21 (8): 1847–1860. (August 2007). doi:10.1210/me.2006-0514. PMID 17505058. 
  28. ^ “Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha”. The Journal of Biological Chemistry 276 (41): 38272–38279. (October 2001). doi:10.1074/jbc.M103783200. PMID 11481323. 
  29. ^ “Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action”. Oncogene 16 (19): 2513–2526. (May 1998). doi:10.1038/sj.onc.1201783. PMID 9627117. 
  30. ^ “The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes”. Molecular and Cellular Biology 23 (6): 1843–1855. (March 2003). doi:10.1128/MCB.23.6.1843-1855.2003. PMC 149455. PMID 12612060. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC149455/. 
  31. ^ “The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1”. Archives of Biochemistry and Biophysics 373 (1): 163–174. (January 2000). doi:10.1006/abbi.1999.1552. PMID 10620335. 
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