Template:PBB/5045

Furin (paired basic amino acid cleaving enzyme)
1p8jをベースにしたPDBによる描画
PDBに登録されている構造 PDB Ortholog search: PDBe, RCSB, PDBj PDBのIDコード一覧 1p8j​
識別記号
記号	FURIN; FUR; PACE; PCSK3; SPC1
その他ID	OMIM: 136950 MGI: 97513 HomoloGene: 1930 GeneCards: FURIN Gene
EC番号	3.4.21.75
遺伝子オントロジー 分子機能 • protease binding • endopeptidase activity • serine-type endopeptidase activity • serine-type endopeptidase activity • serine-type endopeptidase inhibitor activity • protein binding • peptidase activity • peptide binding • metal ion binding • nerve growth factor binding 細胞の構成要素 • Golgi membrane • extracellular space • endoplasmic reticulum membrane • Golgi apparatus • Golgi lumen • trans-Golgi network • plasma membrane • cell surface • integral to membrane • trans-Golgi network transport vesicle • Golgi cisterna • membrane raft 生物学的プロセス • signal peptide processing • proteolysis • transforming growth factor beta receptor signaling pathway • Notch signaling pathway • aging • cell proliferation • peptide hormone processing • peptidyl-glutamic acid carboxylation • viral assembly, maturation, egress, and release • positive regulation of cell migration • positive regulation of transforming growth factor beta receptor signaling pathway • nerve growth factor processing • negative regulation of low-density lipoprotein particle receptor catabolic process • nerve growth factor production • negative regulation of nerve growth factor production • negative regulation of transforming growth factor-beta1 production • secretion by cell • regulation of protein catabolic process • peptide biosynthetic process • post-translational protein modification • cellular protein metabolic process • nerve growth factor receptor signaling pathway • positive regulation of membrane protein ectodomain proteolysis • protein maturation by peptide bond cleavage • protein maturation by peptide bond cleavage • regulation of endopeptidase activity 出典: Amigo / EGO
RNA発現パターン
その他参照発現データ
オルソログ
種	ヒト	マウス
Entrez	5045	18550
Ensembl	ENSG00000140564	ENSMUSG00000030530
UniProt	P09958	Q6GTN6
RefSeq (mRNA)	NM_002569.2	XM_980423
RefSeq (protein)	NP_002560.1	XP_985517
Location (UCSC)	Chr 15: 91.41 - 91.43 Mb	Chr 7: 87.53 - 87.55 Mb
PubMed search	[1]	[2]
KEGG GENES	hsa:5045	mmu:18550