NAD(P)Hオキシダーゼ

NAD(P)Hオキシダーゼ
識別子
EC番号	1.6.3.1
データベース
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB構造	RCSB PDB PDBj PDBe PDBsum
遺伝子オントロジー	AmiGO / QuickGO
検索 PMC articles PubMed articles NCBI proteins

NAD(P)Hオキシダーゼ（NAD(P)H oxidase）は、次の化学反応を触媒する酸化還元酵素である。

NAD(P)H + H⁺ + O₂ $\rightleftharpoons$ NAD(P)⁺ + H₂O₂

反応式の通り、この酵素の基質はNADH（NADPH）とH⁺とO₂、生成物はNAD⁺（NADP⁺）とH₂O₂である。

組織名はNAD(P)H:oxygen oxidoreductaseで、別名にTHOX2; ThOX; dual oxidase; p138tox; thyroid NADPH oxidase; thyroid oxidase; thyroid oxidase 2; NADPH oxidaseがある。

参考文献

• Vijlder JJ, Vulsma T, Ris-Stalpers C (2002). “Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism”. N. Engl. J. Med. 347: 95–102. doi:10.1056/NEJMoa012752. PMID 12110737. 
• De Deken X, Wang D, Dumont JE, Miot F (2002). “Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system”. Exp. Cell. Res. 273: 187–96. doi:10.1006/excr.2001.5444. PMID 11822874. 
• Dumont JE, Miot F (2000). “Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family”. J. Biol. Chem. 275: 23227–33. doi:10.1074/jbc.M000916200. PMID 10806195. 
• Dupuy C, Ohayon R, Valent A, Noel-Hudson MS, Deme D, Virion A (1999). “Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas”. J. Biol. Chem. 274: 37265–9. doi:10.1074/jbc.274.52.37265. PMID 10601291. 
• Carvalho D, Dupuy C, Virion A (1999). “Biochemical characterization of a Ca2+/NAD(P)H-dependent H2O2 generator in human thyroid tissue”. Biochimie. 81: 373–80. doi:10.1016/S0300-9084(99)80084-4. PMID 10401672. 
• Dupuy C, Virion A, Ohayon R, Kaniewski J, Deme D, Pommier J (1991). “Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane”. J. Biol. Chem. 266: 3739–43. PMID 1995628.