3-ヒドロキシアシルCoAデヒドロゲナーゼ
| 3-ヒドロキシアシルCoAデヒドロゲナーゼ | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| 識別子 | |||||||||
| EC番号 | 1.1.1.35 | ||||||||
| CAS登録番号 | 9028-40-4 | ||||||||
| データベース | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB構造 | RCSB PDB PDBj PDBe PDBsum | ||||||||
| 遺伝子オントロジー | AmiGO / QuickGO | ||||||||
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3-ヒドロキシアシルCoAデヒドロゲナーゼ（3-hydroxyacyl-CoA dehydrogenase）は、次の化学反応を触媒する酸化還元酵素である。
- (S)-3-ヒドロキシアシルCoA + NAD+ 3-オキソアシルCoA + NADH + H+
反応式の通り、この酵素の基質は(S)-3-ヒドロキシアシルCoAとNAD+、生成物は3-オキソアシルCoAとNADHとH+である。
組織名は(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductaseで、別名にβ-hydroxyacyl dehydrogenase, β-keto-reductase, 3-keto reductase, 3-hydroxyacyl coenzyme A dehydrogenase, β-hydroxyacyl-coenzyme A synthetase, β-hydroxyacylcoenzyme A dehydrogenase, β-hydroxybutyrylcoenzyme A dehydrogenase, 3-hydroxyacetyl-coenzyme A dehydrogenase, L-3-hydroxyacyl coenzyme A dehydrogenase, L-3-hydroxyacyl CoA dehydrogenase, β-hydroxyacyl CoA dehydrogenase, β-hydroxyacyl coenzyme A dehydrogenase, 3-hydroxybutyryl-CoA dehydrogenase, β-ketoacyl-CoA reductase, β-hydroxy acid dehydrogenase, 3-L-hydroxyacyl-CoA dehydrogenase, 3-hydroxyisobutyryl-CoA dehydrogenase, 1-specific DPN-linked beta-hydroxybutyric dehydrogenaseがある。
参考文献
[編集]- Hillmer P and Gottschalk G (1974). “Solubilization and partial characterisation of particulate dehydrogenases from Clostridium kluyveri”. Biochim. Biophys. Acta 334: 12–23.
- LEHNINGER AL, GREVILLE GD (1953). “The enzymic oxidation of alpha- and 2-beta-hydroxybutyrate”. Biochim. Biophys. Acta. 12: 188–202. doi:10.1016/0006-3002(53)90138-3. PMID 13115428.
- Stern JR (1957). “Crystalline beta-hydroxybutyrate dehydrogenase from pig heart”. Biochim. Biophys. Acta 26: 448–449. doi:10.1016/0006-3002(57)90040-9.
- Wakil SJ, Green DE, Mii S and Mahler HR (1954). “Studies on the fatty acid oxidizing system of animal tissues. VI beta-Hydroxyacyl coenzyme A dehydrogenase”. J. Biol. Chem. 207: 631–638.