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芳香族炭化水素受容体核内輸送体

出典: フリー百科事典『ウィキペディア(Wikipedia)』
ARNT
PDBに登録されている構造
PDBオルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧

4PKY, 1X0O, 2A24, 2B02, 2HV1, 2K7S, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4EQ1, 4GHI, 4GS9, 4H6J, 4LPZ, 4XT2

識別子
記号ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2, aryl hydrocarbon receptor nuclear translocator, Aryl hydrocarbon receptor nuclear translocator
外部IDOMIM: 126110 MGI: 88071 HomoloGene: 1261 GeneCards: ARNT
遺伝子の位置 (ヒト)
1番染色体 (ヒト)
染色体1番染色体 (ヒト)[1]
1番染色体 (ヒト)
ARNT遺伝子の位置
ARNT遺伝子の位置
バンドデータ無し開始点150,809,713 bp[1]
終点150,876,708 bp[1]
遺伝子の位置 (マウス)
3番染色体 (マウス)
染色体3番染色体 (マウス)[2]
3番染色体 (マウス)
ARNT遺伝子の位置
ARNT遺伝子の位置
バンドデータ無し開始点95,341,699 bp[2]
終点95,404,551 bp[2]
RNA発現パターン




さらなる参照発現データ
遺伝子オントロジー
分子機能 sequence-specific DNA binding
DNA結合
protein dimerization activity
DNA-binding transcription factor activity
transcription coactivator activity
aryl hydrocarbon receptor binding
転写因子結合
血漿タンパク結合
protein heterodimerization activity
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
DNA-binding transcription factor activity, RNA polymerase II-specific
protein homodimerization activity
sequence-specific double-stranded DNA binding
nuclear receptor activity
細胞の構成要素 細胞質
transcription regulator complex
核質
RNA polymerase II transcription regulator complex
細胞核
核内構造体
生物学的プロセス positive regulation of vascular endothelial growth factor receptor signaling pathway
細胞分化
低酸素症への反応
regulation of transcription, DNA-templated
positive regulation of endothelial cell proliferation
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
positive regulation of erythrocyte differentiation
embryonic placenta development
mRNA transcription by RNA polymerase II
positive regulation of protein sumoylation
transcription, DNA-templated
positive regulation of transcription, DNA-templated
intracellular receptor signaling pathway
regulation of transcription from RNA polymerase II promoter in response to hypoxia
positive regulation of vascular endothelial growth factor production
positive regulation of glycolytic process
positive regulation of transcription by RNA polymerase II
positive regulation of hormone biosynthetic process
生体異物の代謝プロセス
出典:Amigo / QuickGO
オルソログ
ヒトマウス
Entrez
Ensembl
UniProt
RefSeq
(mRNA)
NM_001197325
NM_001286035
NM_001286036
NM_001668
NM_178426

NM_178427
NM_001350224
NM_001350225
NM_001350226

NM_001037737
NM_009709

RefSeq
(タンパク質)
NP_001184254
NP_001272964
NP_001272965
NP_001659
NP_848514

NP_001337153
NP_001337154
NP_001337155

NP_001032826
NP_033839

場所
(UCSC)
Chr 1: 150.81 – 150.88 MbChr 1: 95.34 – 95.4 Mb
PubMed検索[3][4]
ウィキデータ
閲覧/編集 ヒト閲覧/編集 マウス

芳香族炭化水素受容体核内輸送体ARNT: aryl hydrocarbon receptor nuclear translocator)は、リガンド結合型芳香族炭化水素受容体(AhR)と複合体を形成するタンパク質であり、AhRが受容体として機能するために必要である。また、低酸素誘導因子1(HIF1)のベータサブユニットとしても知られている。TEL-ARNT融合タンパク質の発現をもたらす遺伝子座のt(1; 12)(q21; p13)転座は、急性骨髄芽球性白血病と関連している。この遺伝子について、異なるアイソフォームをコードする3つのスプライスバリアントが報告されている。

AhRは、生体異物代謝に関与するいくつかの酵素の誘導に関与している。リガンドを含まない、細胞質ゾル型のAhRは、熱ショックタンパク質90(Hsp90)と複合体を形成する。ダイオキシン多環芳香族炭化水素を含むリガンドの結合は、リガンド結合サブユニットの核への転座をもたらす[5]。生体異物代謝に関与する酵素の誘導は、これら酵素の遺伝子のプロモーター内の生体異物応答エレメントへのリガンド結合型AhRの結合を介して発生する。

相互作用分子

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ARNTは、以下の生体分子と相互作用する。

脚注

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143437 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015522 - Ensembl, May 2017
  3. ^ Human PubMed Reference:
  4. ^ Mouse PubMed Reference:
  5. ^ Duncan Hughes, Joseph B. Guttenplan, Craig B. Marcus, Kotha Subbaramaiah and Andrew J. Dannenberg (5 November 2008). “Heat Shock Protein 90 Inhibitors Suppress Aryl Hydrocarbon Receptor-Mediated Activation of CYP1A1 and CYP1B1 Transcription and DNA Adduct Formation”. Cancer Prevention Research 1 (6): 485–493. doi:10.1158/1940-6207.CAPR-08-0149. PMC 2680610. PMID 19138996. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680610/. 
  6. ^ Lucy A. Carver, Christopher A. Bradfield (25 April 1997). “Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo”. Journal of Biological Chemistry 272 (17): 11452–6. doi:10.1074/jbc.272.17.11452. PMID 9111057. 
  7. ^ Arunas Kazlauskas, Sara Sundström, Lorenz Poellinger, and Ingemar Pongratz (April 2001). “The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor”. Molecular and Cellular Biology 21 (7): 2594–607. doi:10.1128/MCB.21.7.2594-2607.2001. PMC 86890. PMID 11259606. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC86890/. 
  8. ^ M.C. Lindebro, L. Poellinger, M.L. Whitelaw (01 July 1995). “Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex”. EMBO Journal 14 (14): 3528–39. doi:10.1002/j.1460-2075.1995.tb07359.x. PMC 394421. PMID 7628454. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC394421/. 
  9. ^ M Whitelaw, I Pongratz, A Wilhelmsson, J A Gustafsson, L Poellinger (April 1993). “Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor”. Molecular and Cellular Biology 13 (4): 2504–14. doi:10.1128/MCB.13.4.2504. PMC 359572. PMID 8384309. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC359572/. 
  10. ^ Yumi Yamaguchi, M. Tien Kuo (12 October 1995). “Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two-hybrid system”. Biochemical Pharmacology 50 (8): 1295–302. doi:10.1016/0006-2952(95)02016-6. PMID 7488247. 
  11. ^ Junsei Mimura, Masatsugu Ema, Kazuhiro Sogawa, and Yoshiaki Fujii-Kuriyama (01 January 1999). “Identification of a novel mechanism of regulation of Ah (dioxin) receptor function”. Genes & Development 13 (1): 20–5. doi:10.1101/gad.13.1.20. PMC 316371. PMID 9887096. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC316371/. 
  12. ^ a b John B. Hogenesch, William K. Chan, Victoria H. Jackiw, R. Clark Brown, Yi-Zhong Gu, Marilyn Pray-Grant, Gary H. Perdew, Christopher A. Bradfield (28 March 1997). “Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway”. Journal of Biological Chemistry 272 (13): 8581–93. doi:10.1074/jbc.272.13.8581. PMID 9079689. 
  13. ^ a b c Susan L. Woods, Murray L. Whitelaw (22 March 2002). “Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors”. Journal of Biological Chemistry 277 (12): 10236–43. doi:10.1074/jbc.M110752200. PMID 11782478. 
  14. ^ Timothy V Beischlag, Song Wang, David W Rose, Joseph Torchia, Suzanne Reisz-Porszasz, Khurshid Muhammad, Walter E Nelson, Markus R Probst, Michael G Rosenfeld, Oliver Hankinson (15 June 2002). “Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex”. Molecular and Cellular Biology 22 (12): 4319–33. doi:10.1128/mcb.22.12.4319-4333.2002. PMC 133867. PMID 12024042. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC133867/. 
  15. ^ a b Markus R. Probst, Chen-Ming Fan, Marc Tessier-Lavigne, Oliver Hankinson (14 February 1997). “Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein”. Journal of Biological Chemistry 272 (7): 4451–7. doi:10.1074/jbc.272.7.4451. PMID 9020169. 
  16. ^ Norihisa Ooe, Koichi Saito, Nobuyoshi Mikami, Iwao Nakatuka, Hideo Kaneko (15 January 2004). “Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression”. Molecular and Cellular Biology 24 (2): 608–16. doi:10.1128/mcb.24.2.608-616.2004. PMC 343817. PMID 14701734. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC343817/. 
  17. ^ P Moffett, M Reece, J Pelletier (September 1997). “The murine Sim-2 gene product inhibits transcription by active repression and functional interference”. Molecular and Cellular Biology 17 (9): 4933–47. doi:10.1128/mcb.17.9.4933. PMC 232345. PMID 9271372. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC232345/. 

参考文献

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外部リンク

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