マグノリシン

マグノリシン(Magnolysin、EC 3.4.24.62)は、酵素である^[1]^[2]^[3]^[4]^[5]。この酵素は、例えばオキシトシン前駆体の-Lys-Arg-Ala-Val-結合等、ポリペプチドのP1位またはP2位のアルギニンまたはリシンの結合を切断する反応を触媒する酵素である。

この酵素は、ウシの下垂体神経分泌顆粒に存在する。

出典

^ Clamagirand, C., Creminon, C., Fahy, C., Boussetta, H. and Cohen, P. (1987). “Partial purification and functional properties of an endoprotease from bovine neurosecretory granules cleaving proocytosin/neurophysin peptides at the basic amino acid doublet”. Biochemistry 26: 6018-6023. PMID 2825769.
^ Créminon, C., Rholam, M., Boussetta, H., Marrakchi, N. and Cohen, P. (1988). “Synthetic peptide substrates as models to study a pro-ocytocin/neurophysin converting enzyme”. J. Chromatogt. 440: 439-448. PMID 3042797.
^ Brakch, N., Boussetta, H., Rholam, M. and Cohen, P. (1989). “Processing endoprotease recognizes a structural feature at the cleavage site of peptide prohormones. The pro-ocytocin/neurophysin model”. J. Biol. Chem. 264: 15912-15916. PMID 2674120.
^ Plevrakis, I, Créminon, C., Clamagirand, C., Brakch, N., Rholam, M. and Cohen, P. (1989). “Proocytocin/neurophysin convertase from bovine neurohypophysis and corpus luteum secretory granules: complete purification, structure-function relationships, and competitive inhibitor”. Biochemistry 28: 2705-2710. PMID 2659078.
^ Guillou, M.D., Camier, M. and Clamagirand, C. (1994). “Evidence for the presence of pro-oxytocin/neurophysin converting enzyme in the human ovary”. J. Endocrinol. 142: 345-352. PMID 7931007.