ピレスロイドヒドロラーゼ

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ピレスロイドヒドロラーゼ
識別子
EC番号	3.1.1.88
データベース
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB構造	RCSB PDB PDBj PDBe PDBsum
検索
PMC	articles
PubMed	articles
NCBI	proteins
	テンプレートを表示

ピレスロイドヒドロラーゼ(Pyrethroid hydrolase、EC 3.3.1.88)は、以下の化学反応を触媒する酵素である。

トランス-ペルメトリン + 水

\rightleftharpoons

(3-フェノキシフェニル)メタノール + (1S,3R)-3-(2,2-ジクロロエテニル)-2,2-ジメチルシクロプロパンカルボン酸

この酵素は、ピレスロイド系農薬の分解に関与している。

系統名は、ピレスロイド-エステルヒドロラーゼ(pyrethroid-ester hydrolase)である^[1]^[2]^[3]^[4]^[5]^[6]。ペルメトリナーゼ、PytH、EstP等とも呼ばれる。

出典

^ Wang, B.Z., Guo, P., Hang, B.J., Li, L., He, J. and Li, S.P. (2009). “Cloning of a novel pyrethroid-hydrolyzing carboxylesterase gene from Sphingobium sp. strain JZ-1 and characterization of the gene product”. Appl. Environ. Microbiol. 75: 5496–5500. PMID 19581484.
^ Wu, P.C., Liu, Y.H., Wang, Z.Y., Zhang, X.Y., Li, H., Liang, W.Q., Luo, N., Hu, J.M., Lu, J.Q., Luan, T.G. and Cao, L.X. (2006). “Molecular cloning, purification, and biochemical characterization of a novel pyrethroid-hydrolyzing esterase from Klebsiella sp. strain ZD112”. J. Agric. Food Chem. 54: 836–842. PMID 16448191.
^ Liang, W.Q., Wang, Z.Y., Li, H., Wu, P.C., Hu, J.M., Luo, N., Cao, L.X. and Liu, Y.H. (2005). “Purification and characterization of a novel pyrethroid hydrolase from Aspergillus niger ZD11”. J. Agric. Food Chem. 53: 7415–7420. PMID 16159167.
^ Stok, J.E., Huang, H., Jones, P.D., Wheelock, C.E., Morisseau, C. and Hammock, B.D. (2004). “Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes”. J. Biol. Chem. 279: 29863–29869. PMID 15123619.
^ Maloney, S.E., Maule, A. and Smith, A.R. (1993). “Purification and preliminary characterization of permethrinase from a pyrethroid-transforming strain of Bacillus cereus”. Appl. Environ. Microbiol. 59: 2007–2013. PMID 8357241.
^ Guo, P., Wang, B., Hang, B., Li, L., Ali, W., He, J. and Li, S. (2009). “Pyrethroid-degrading Sphingobium sp. JZ-2 and the purification and characterization of a novel pyrethroid hydrolase”. Int. Biodeter. Biodegrad. 63: 1107–1112.

外部リンク

Pyrethroid hydrolase - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語）

[1] Wang, B.Z., Guo, P., Hang, B.J., Li, L., He, J. and Li, S.P. (2009). “Cloning of a novel pyrethroid-hydrolyzing carboxylesterase gene from Sphingobium sp. strain JZ-1 and characterization of the gene product”. Appl. Environ. Microbiol. 75: 5496–5500. PMID 19581484.

[2] Wu, P.C., Liu, Y.H., Wang, Z.Y., Zhang, X.Y., Li, H., Liang, W.Q., Luo, N., Hu, J.M., Lu, J.Q., Luan, T.G. and Cao, L.X. (2006). “Molecular cloning, purification, and biochemical characterization of a novel pyrethroid-hydrolyzing esterase from Klebsiella sp. strain ZD112”. J. Agric. Food Chem. 54: 836–842. PMID 16448191.

[3] Liang, W.Q., Wang, Z.Y., Li, H., Wu, P.C., Hu, J.M., Luo, N., Cao, L.X. and Liu, Y.H. (2005). “Purification and characterization of a novel pyrethroid hydrolase from Aspergillus niger ZD11”. J. Agric. Food Chem. 53: 7415–7420. PMID 16159167.

[4] Stok, J.E., Huang, H., Jones, P.D., Wheelock, C.E., Morisseau, C. and Hammock, B.D. (2004). “Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes”. J. Biol. Chem. 279: 29863–29869. PMID 15123619.

[5] Maloney, S.E., Maule, A. and Smith, A.R. (1993). “Purification and preliminary characterization of permethrinase from a pyrethroid-transforming strain of Bacillus cereus”. Appl. Environ. Microbiol. 59: 2007–2013. PMID 8357241.

[6] Guo, P., Wang, B., Hang, B., Li, L., Ali, W., He, J. and Li, S. (2009). “Pyrethroid-degrading Sphingobium sp. JZ-2 and the purification and characterization of a novel pyrethroid hydrolase”. Int. Biodeter. Biodegrad. 63: 1107–1112.

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