スルファジミジン

スルファジミジン
スルファメタジン
IUPAC命名法による物質名
	IUPAC名 4-amino-N-(4,6-dimethylpyrimidin-2-yl); benzene-1-sulfonamide;
臨床データ
Drugs.com	国別販売名(英語); International Drug Names
データベースID
CAS番号;	57-68-1
ATCコード	J01EB03 (WHO) QJ01EQ03 (WHO) QP51AG01 (WHO) QP51AG51 (WHO)
PubChem	CID: 5327
DrugBank	DB01582
ChemSpider	5136
UNII	48U51W007F
KEGG	D02436
ChEBI	CHEBI:102265
ChEMBL	CHEMBL446
NIAID ChemDB	027749
化学的データ
化学式	C12H14N4O2S
分子量	278.33 g·mol−1
	SMILES O=S(=O)(Nc1nc(cc(n1)C)C)c2ccc(N)cc2;
	InChI InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16) ; Key:ASWVTGNCAZCNNR-UHFFFAOYSA-N ;
物理的データ
融点	176 °C (349 °F)
	テンプレートを表示

スルファジミジン（英：Sulfadimidine ）または、スルファメタジン（英：Sulfamethazine ）は、スルホンアミド系抗菌薬である。

スルファジミジン（SDI^[1]^[2]や一般的に用いられるが確実性の低い^bSDD^[3]^[4]）、スルファメタジン（SMT^[5]^[6]、や一般的に用いられるが確実性の低い^c SMZ^[7]^[8]）のように標準化されていない略語がある^a。他の名称としてスルファジメラジン、スルファジメジン、スルファジメチルピリミジンなどがある^[要出典]。

脚注

^ “Sulfonamide residues in eggs”. Acta Veterinaria Hungarica 40 (1–2): 99–106. (1992). PMID 1476095.
^ “Pharmacokinetic studies of sulphonamides in poultry”. Indian Journal of Animal Sciences. (1988).
^ “[Studies on the identification of sulfadimidine in pork by high performance liquid chromatography with photodiode array detector and gas chromatograph-mass spectrometry]”. Eisei Shikenjo Hokoku. Bulletin of National Institute of Hygienic Sciences (111): 61–5. (1993). PMID 7920569.
^ “Comparative pharmacokinetic study of four different sulfonamides in combination with trimethoprim in human volunteers”. International Journal of Clinical Pharmacology, Therapy, and Toxicology 24 (1): 23–5. (January 1986). PMID 3485584.
^ “Solvent effect on the determination of sulfamethazine by room-temperature photochemically induced fluorescence”. Talanta 41 (2): 233–6. (February 1994). doi:10.1016/0039-9140(94)80113-4. PMID 18965913.
^ “Photocatalytic oxidation of sulfamethazine”. Chemosphere 60 (3): 372–80. (July 2005). Bibcode: 2005Chmsp..60..372K. doi:10.1016/j.chemosphere.2004.11.069. PMID 15924956.
^ “Sulfamethazine absorption and disposition: effect of surgical procedures for gastroduodenal ulcers”. Biopharmaceutics & Drug Disposition 8 (2): 115–24. (Mar 1987). doi:10.1002/bdd.2510080203. PMID 3593892.
^ “The toxicity of sulfamethazine to Daphnia magna and its additivity to other veterinary sulfonamides and trimethoprim”. Chemosphere 75 (11): 1519–24. (June 2009). Bibcode: 2009Chmsp..75.1519D. doi:10.1016/j.chemosphere.2009.02.002. PMID 19269673.

参考文献

ChemDB. "Sulfamethazine", ChemDB, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)

[1] “Sulfonamide residues in eggs”. Acta Veterinaria Hungarica 40 (1–2): 99–106. (1992). PMID 1476095.

[2] “Pharmacokinetic studies of sulphonamides in poultry”. Indian Journal of Animal Sciences. (1988).

[3] “[Studies on the identification of sulfadimidine in pork by high performance liquid chromatography with photodiode array detector and gas chromatograph-mass spectrometry]”. Eisei Shikenjo Hokoku. Bulletin of National Institute of Hygienic Sciences (111): 61–5. (1993). PMID 7920569.

[4] “Comparative pharmacokinetic study of four different sulfonamides in combination with trimethoprim in human volunteers”. International Journal of Clinical Pharmacology, Therapy, and Toxicology 24 (1): 23–5. (January 1986). PMID 3485584.

[5] “Solvent effect on the determination of sulfamethazine by room-temperature photochemically induced fluorescence”. Talanta 41 (2): 233–6. (February 1994). doi:10.1016/0039-9140(94)80113-4. PMID 18965913.

[6] “Photocatalytic oxidation of sulfamethazine”. Chemosphere 60 (3): 372–80. (July 2005). Bibcode: 2005Chmsp..60..372K. doi:10.1016/j.chemosphere.2004.11.069. PMID 15924956.

[7] “Sulfamethazine absorption and disposition: effect of surgical procedures for gastroduodenal ulcers”. Biopharmaceutics & Drug Disposition 8 (2): 115–24. (Mar 1987). doi:10.1002/bdd.2510080203. PMID 3593892.

[8] “The toxicity of sulfamethazine to Daphnia magna and its additivity to other veterinary sulfonamides and trimethoprim”. Chemosphere 75 (11): 1519–24. (June 2009). Bibcode: 2009Chmsp..75.1519D. doi:10.1016/j.chemosphere.2009.02.002. PMID 19269673.

[1]

[2]

b

[3]

[4]

[5]

[6]

c

[7]

[8]

a