Chimerin 2
（CHN2から転送）
β-chimaerin（ベータ-キメリン、ベータ-カイメリン）はヒトにおいてCHN2遺伝子にコードされているタンパク質である[4][5]。
この遺伝子はchimerinファミリーのメンバーであり、ホルボールエステル/DAGタイプ亜鉛フィンガー、Rho-GAPドメイン、SH2ドメインを持つタンパク質をコードしている。このタンパク質は、リン脂質結合およびジアシルグリセロール (DAG) の結合が誘導するタンパク質の細胞質ゾルからゴルジ体膜への移行によって制御されているGTPアーゼ活性化タンパク質活性を有する。このタンパク質は平滑筋細胞の増殖および移動に役割を果たしている。この遺伝子の発現の減少は悪性度の高い神経膠腫および乳がんと関連しており、この遺伝子の発現の上昇はリンパ腫と関連している。この遺伝子の変異は、ヒトの統合失調症と関連している。異なるアイソフォームをコードしている選択的転写スプライシングバリアントが同定されている[5]。
脚注
[編集]- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004633 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ Leung T, How BE, Manser E, Lim L (Jun 1994), “Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain”, J Biol Chem 269 (17): 12888–92, PMID 8175705
- ^ a b “Entrez Gene: CHN2 chimerin (chimaerin) 2”. 2012年1月26日閲覧。
推薦文献
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- Caloca MJ, Fernandez N, Lewin NE, et al. (1997), “Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters”, J. Biol. Chem. 272 (42): 26488–96, doi:10.1074/jbc.272.42.26488, PMID 9334226
- Caloca MJ, Garcia-Bermejo ML, Blumberg PM, et al. (1999), “beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain”, Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11854–9, doi:10.1073/pnas.96.21.11854, PMC 18376, PMID 10518540
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- Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005), “High-throughput mapping of a dynamic signaling network in mammalian cells”, Science 307 (5715): 1621–5, doi:10.1126/science.1105776, PMID 15761153
- Yang C, Liu Y, Leskow FC, et al. (2005), “Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin.”, J. Biol. Chem. 280 (26): 24363–70, doi:10.1074/jbc.M411629200, PMID 15863513
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