サイクリンD3

CCND3
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	3G33
識別子
記号	CCND3, cyclin D3
外部ID	OMIM: 123834 MGI: 88315 HomoloGene: 20419 GeneCards: CCND3
遺伝子の位置 (ヒト)
染色体	6番染色体 (ヒト)
終点	42,050,357 bp
遺伝子の位置 (マウス)
染色体	17番染色体 (マウス)
終点	47,910,616 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• cyclin-dependent protein serine/threonine kinase activity; • 血漿タンパク結合; • プロテインキナーゼ結合; • protein kinase activity; • cyclin-dependent protein serine/threonine kinase regulator activity;
細胞の構成要素	• 核質; • cyclin-dependent protein kinase holoenzyme complex; • 膜; • 細胞核; • 細胞質;
生物学的プロセス	• T cell proliferation; • 細胞周期; • positive regulation of protein phosphorylation; • シグナル伝達; • positive regulation of cyclin-dependent protein serine/threonine kinase activity; • regulation of cell cycle; • 細胞分裂; • negative regulation of transcription by RNA polymerase II; • regulation of cell population proliferation; • regulation of insulin receptor signaling pathway; • regulation of cyclin-dependent protein serine/threonine kinase activity; • 体細胞分裂; • タンパク質リン酸化; • regulation of mitotic nuclear division; • positive regulation of cell population proliferation; • positive regulation of cell cycle; • positive regulation of G1/S transition of mitotic cell cycle;
	出典:Amigo / QuickGO
オルソログ
	896
	12445
	ENSG00000112576
	ENSMUSG00000034165
	P30281
	P30282
NM_001136017; NM_001136125; NM_001136126; NM_001287427; NM_001287434;
	NM_001760
	NM_001081635; NM_001081636; NM_007632
NP_001129489; NP_001129597; NP_001129598; NP_001274356; NP_001274363;
	NP_001751
	NP_001075104; NP_001075105; NP_031658
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

→「サイクリンD」も参照

サイクリンD3（英: cyclin D3）は、ヒトではCCND3遺伝子にコードされるタンパク質である^[5]。

機能

CCND3遺伝子によってコードされるサイクリンD3は、高度に保存されたサイクリンファミリーに属する。このファミリーのメンバーは、細胞周期を通じてタンパク質の存在量に劇的な周期的変化が生じることで特徴づけられる。サイクリンはサイクリン依存性キナーゼの調節因子として機能する。さまざまなサイクリンはそれぞれ異なる発現と分解のパターンを持ち、有糸分裂の各イベントの時間的調整に寄与する。このサイクリンはCDK4またはCDK6と複合体を形成し、これらの調節サブユニットとして機能する。これらの活性はG₁期からS期への移行に必要である。このタンパク質は、がん抑制因子であるRbタンパク質と相互作用し、そのリン酸化に関与していることが示されている。このサイクリンと関係したCDK4の活性は、紫外線照射後の細胞周期のG₂期から有糸分裂への進行に必要であることが報告されている^[6]。

臨床的意義

CCND3遺伝子の変異は、乳がん症例との関係が示唆されている^[7]。

相互作用

サイクリンD3は次に挙げる因子と相互作用することが示されている。

出典

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112576 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034165 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “Genomic organization, chromosomal localization, and independent expression of human cyclin D genes”. Genomics 13 (3): 565–74. (August 1992). doi:10.1016/0888-7543(92)90126-D. PMID 1386335.
^ “Entrez Gene: CCND3 cyclin D3”. 2021年12月3日閲覧。
^ Koboldt, Daniel C.; Fulton, Robert S.; McLellan, Michael D.; Schmidt, Heather; Kalicki-Veizer, Joelle; McMichael, Joshua F.; Fulton, Lucinda L.; Dooling, David J. et al. (2012). “Comprehensive molecular portraits of human breast tumours”. Nature 490 (7418): 61–70. Bibcode: 2012Natur.490...61T. doi:10.1038/nature11412. PMC 3465532. PMID 23000897.
^ ^a ^b “A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95”. Biochem. J. 378 (Pt 2): 673–9. (2004). doi:10.1042/BJ20031765. PMC 1223988. PMID 14641107.
^ “Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3”. J. Biol. Chem. 277 (38): 35314–22. (2002). doi:10.1074/jbc.M202179200. PMID 12082095.
^ ^a ^b “Towards a proteome-scale map of the human protein-protein interaction network”. Nature 437 (7062): 1173–8. (2005). Bibcode: 2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
^ ^a ^b ^c “Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence”. Oncogene 20 (16): 2000–9. (2001). doi:10.1038/sj.onc.1204375. PMID 11360184.
^ ^a ^b “Developmentally regulated expression of cyclin D3 and its potential in vivo interacting proteins during murine gametogenesis”. Endocrinology 140 (6): 2790–800. (1999). doi:10.1210/endo.140.6.6756. PMID 10342870.
^ ^a ^b “Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II”. J. Biol. Chem. 278 (8): 6355–62. (2003). doi:10.1074/jbc.M210697200. PMID 12482873.
^ “Identification of G1 kinase activity for cdk6, a novel cyclin D partner”. Mol. Cell. Biol. 14 (3): 2077–86. (1994). doi:10.1128/MCB.14.3.2077. PMC 358568. PMID 8114739.
^ “Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3”. FEBS Lett. 573 (1–3): 139–46. (2004). doi:10.1016/j.febslet.2004.07.071. PMID 15327989.

関連文献

“Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene”. J. Biol. Chem. 267 (28): 20412–5. (1992). PMID 1383201.
“Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins”. Genomics 13 (3): 575–84. (1992). doi:10.1016/0888-7543(92)90127-E. PMID 1386336.
“Assignment of the human cyclin D3 gene (CCND3) to chromosome 6p----q13”. Cytogenet. Cell Genet. 61 (1): 5–7. (1992). doi:10.1159/000133359. PMID 1387066.
“D-type cyclin-binding regions of proliferating cell nuclear antigen”. J. Biol. Chem. 269 (15): 11030–6. (1994). PMID 7908906.
“Identification of G1 kinase activity for cdk6, a novel cyclin D partner”. Mol. Cell. Biol. 14 (3): 2077–86. (1994). doi:10.1128/MCB.14.3.2077. PMC 358568. PMID 8114739.
“Physical interaction of the retinoblastoma protein with human D cyclins”. Cell 73 (3): 499–511. (1993). doi:10.1016/0092-8674(93)90137-F. PMID 8490963.
“Functional analysis of the human cyclin D2 and cyclin D3 promoters”. J. Biol. Chem. 271 (15): 9090–9. (1996). doi:10.1074/jbc.271.15.9090. PMID 8621559.
“Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest”. Mol. Cell. Biol. 16 (7): 3934–44. (1996). doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
“Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1”. Mol. Cell. Biol. 16 (11): 6457–67. (1996). doi:10.1128/MCB.16.11.6457. PMC 231647. PMID 8887674.
“Cyclin D3 expression in normal, reactive and neoplastic tissues”. J. Pathol. 185 (2): 159–66. (1998). doi:10.1002/(SICI)1096-9896(199806)185:2<159::AID-PATH73>3.0.CO;2-0. PMID 9713342.
“Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo”. Mol. Cell. Biol. 19 (1): 353–63. (1999). doi:10.1128/mcb.19.1.353. PMC 83893. PMID 9858559.
“A cyclin D-Cdk4 activity required for G2 phase cell cycle progression is inhibited in ultraviolet radiation-induced G2 phase delay”. J. Biol. Chem. 274 (20): 13961–9. (1999). doi:10.1074/jbc.274.20.13961. PMID 10318807.
“Developmentally regulated expression of cyclin D3 and its potential in vivo interacting proteins during murine gametogenesis”. Endocrinology 140 (6): 2790–800. (1999). doi:10.1210/endo.140.6.6756. PMID 10342870.
“D-type cyclins in adult human testis and testicular cancer: relation to cell type, proliferation, differentiation, and malignancy”. J. Pathol. 187 (5): 573–81. (1999). doi:10.1002/(SICI)1096-9896(199904)187:5<573::AID-PATH289>3.0.CO;2-H. PMID 10398124.
“Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells”. Mol. Cell. Biol. 20 (15): 5690–9. (2000). doi:10.1128/MCB.20.15.5690-5699.2000. PMC 86042. PMID 10891505.
“NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity”. Oncogene 19 (43): 5000–9. (2000). doi:10.1038/sj.onc.1203843. PMID 11042687.
“Novel expression of cyclin-dependent kinase inhibitors in human B-cell precursors”. Exp. Hematol. 29 (4): 490–8. (2001). doi:10.1016/S0301-472X(01)00619-1. PMID 11301189.
“Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence”. Oncogene 20 (16): 2000–9. (2001). doi:10.1038/sj.onc.1204375. PMID 11360184.
“Aberrant expression of G1-phase cell cycle regulators in flat and exophytic adenomas of the human colon”. Gastroenterology 120 (7): 1680–8. (2001). doi:10.1053/gast.2001.24880. PMID 11375949.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112576 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034165 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[pmid1386335-5] “Genomic organization, chromosomal localization, and independent expression of human cyclin D genes”. Genomics 13 (3): 565–74. (August 1992). doi:10.1016/0888-7543(92)90126-D. PMID 1386335.

[6] “Entrez Gene: CCND3 cyclin D3”. 2021年12月3日閲覧。

[nature11412-7] Koboldt, Daniel C.; Fulton, Robert S.; McLellan, Michael D.; Schmidt, Heather; Kalicki-Veizer, Joelle; McMichael, Joshua F.; Fulton, Lucinda L.; Dooling, David J. et al. (2012). “Comprehensive molecular portraits of human breast tumours”. Nature 490 (7418): 61–70. Bibcode: 2012Natur.490...61T. doi:10.1038/nature11412. PMC 3465532. PMID 23000897.

[pmid14641107-8] “A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95”. Biochem. J. 378 (Pt 2): 673–9. (2004). doi:10.1042/BJ20031765. PMC 1223988. PMID 14641107.

[pmid12082095-9] “Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3”. J. Biol. Chem. 277 (38): 35314–22. (2002). doi:10.1074/jbc.M202179200. PMID 12082095.

[pmid16189514-10] “Towards a proteome-scale map of the human protein-protein interaction network”. Nature 437 (7062): 1173–8. (2005). Bibcode: 2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

[pmid11360184-11] “Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence”. Oncogene 20 (16): 2000–9. (2001). doi:10.1038/sj.onc.1204375. PMID 11360184.

[pmid10342870-12] “Developmentally regulated expression of cyclin D3 and its potential in vivo interacting proteins during murine gametogenesis”. Endocrinology 140 (6): 2790–800. (1999). doi:10.1210/endo.140.6.6756. PMID 10342870.

[pmid12482873-13] “Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II”. J. Biol. Chem. 278 (8): 6355–62. (2003). doi:10.1074/jbc.M210697200. PMID 12482873.

[pmid8114739-14] “Identification of G1 kinase activity for cdk6, a novel cyclin D partner”. Mol. Cell. Biol. 14 (3): 2077–86. (1994). doi:10.1128/MCB.14.3.2077. PMC 358568. PMID 8114739.

[pmid15327989-15] “Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3”. FEBS Lett. 573 (1–3): 139–46. (2004). doi:10.1016/j.febslet.2004.07.071. PMID 15327989.

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